منابع مشابه
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Tumorigenesis can be seen as an evolutionary process, in which the transformation of a normal cell into a tumor cell involves a number of limiting genetic and epigenetic events, occurring in a series of discrete stages. However, not all mutations in a cell are directly involved in cancer development and it is likely that most of them (passenger mutations) do not contribute in any way to tumorig...
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Tumor suppressor genes (TSGs) are important gatekeepers that protect against somatic evolution of cancer. Losing both alleles of a TSG in a single cell represents a step toward cancer. We study how the kinetics of TSG inactivation depends on the population size of cells and the mutation rates for the first and second hit. We calculate the probability as function of time that at least one cell h...
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In this paper the evolutionary design of a neural network model for predicting nonlinear systems behavior is discussed. In particular, the Breeder Genetic Algorithms are considered to provide the optimal set of synaptic weights of the network. The feasibility of the neural model proposed is demonstrated by predicting the Mackey{ Glass time series. A comparison with Genetic Algorithms and Back P...
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During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively). The switch in coreceptor usage has been correlated with a faster progression of the disease to the AIDS phase. As several pharmaceutical companies are starting large phase III trials for R5 and X4 drugs,...
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News articles on the same event published over time have properties that challenge NLP and IR applications. A cluster of stories typically exhibits instances of paraphrase and contradiction, as sources update the facts, often due to an ongoing investigation. The current hypothesis is that news stories “evolve” over time, beginning with the first text published on a given topic. This is tested u...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2013
ISSN: 1664-042X
DOI: 10.3389/fphys.2012.00480